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newbeauty magazine 2018 award winnerGalderma, a leader in cosmetic fillers has announced Refyne and Defyne as the first flexible and natural appearing dermal fillers which move with each contour and movement of your face.

These products are designed to help smooth out smile and laugh lines while maintaining a natural look, thereby creating a beautiful natural filler effect without any visible signs of having an treatments when you smile and show expression.

We are excited to offer these new products, while applying the expertise we’ve accumulated through years of using Restylane. Say goodbye to stiff looking cheeks and laugh lines!

What’s the difference?

Refyne is best for mild to moderate lines or volume loss in the lower face; particularly around the mouth and is showing incredible promise for hallows under the eyes.

Defyne is approved for moderate to deep line, volume loss and facial contouring.

refyne and defyne video

Natural Results That Refyne Your Laugh Lines Restylane Refyne logo

A next-generation hyaluronic acid dermal filler designed to help support your skin while keeping you looking like you. New Restylane® Refyne is designed to help soften laugh lines (nasolabial folds and marionette lines). This can help you restore a more natural look to your face while maintaining your facial expressions.

The unique cross-linking of the gel in Restylane Refyne is also designed to help support your natural expression—for results that help maintain natural movement when you’re smiling, frowning and even puckering up.

Defyne Your Expression

Invest in yourself with real-life results that help maintain natural movement to help keep you looking like you. New Restylane® Defyne helps smooth out deep laugh lines (nasolabial folds and marionette lines). Using innovative cross-linking technology, Restylane Defyne is a hyaluronic acid dermal filler that is able to help restore a more youthful, natural-looking appearance, while helping you maintain your natural expressions.

Results May Vary


In a clinical study, subjects were evaluated based on perception of the naturalness of facial expressions in motion after 1 month of Restylane Defyne and Restylane Refyne optimal treatment.

• 97% of treated subjects were satisfied with their treatment results
• 97% of treated subjects would do the treatment again
• 95% of treated subjects would recommend the products to a friend

Restylane® Refyne and Defyne are for mid-to-deep injection into the facial tissue for the correction of moderate to severe facial wrinkles and folds, such as nasolabial folds, in patients over the age of 21.


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