( plated )™ SkinScience

( plated ) SkinScience is the first and only topical skincare product harnessing the power of platelet-derived exosomes.

(plated) Skin Science If you’re on the cutting-edge of science and skin care products, you know the buzzword of the last few years is “exosomes”. The buzz is earned! Exosomes are impactful ingredients that we’ve wanted to share with our customers. But until now, exosomes have not been shelf-stable and so could not be distributed in home care products.

Now you can harness the power of exosomes and promote cell growth, form new blood vessels, and reduce inflammation by adding Rion Aesthetics’ (plated) Skin Science Intensive Repair Serum and Revitalizing Essence to your daily at-home regimen.

Right now, within your body, platelets are releasing exosomes which have a job to do:

  1. carry beneficial antioxidant enzymes and proteins,
  2. seek out tissue which is damaged or inflamed, and
  3. deliver growth factors to these injured cells.

(plated) Skin Science’s key proprietary ingredient, Renewosomes™, contains trillions of these hard-working exosomes, extracted from human platelets purchased from FDA-compliant platelet banks. Rion Aesthetics’ studies show that while every cell in your body produces exosomes, only platelet-generated exosomes signal soft tissue renewal. From these “renewing” effect exosomes, the key Renewosomes™ are extracted.

From the cellular level, new collagen is stimulated, decreasing redness and wrinkles and:

  • building firmer skin
  • improving luminosity, skin tone, and texture
  • shrinking pore size
  • targeting free radicals and environmental influences which can trigger cellular aging
  • calming the skin
  • reducing dark spots and broken capillaries

Before and after six weeks of use

Before and after six weeks of use

Before and after six weeks of use

Before and after six weeks of use


Three formulations are available. Revitalizing Essence is intended as part of a daily skin care regimen. Intensive Repair Serum contains double the concentration of Renewosomes™ and is recommended for patients with more damaged skin. Calm is formulated to help soothe the skin after a laser procedure. Complimentary consultations are available in-person or by phone so you can determine which product is best for you.


CalmCalm Plated Exosome Serum
Calm is a platelet-derived serum uniquely designed with a high concentration of Renewosome™ technology to help prepare the skin before, and soothe the skin after a laser procedure. This formulation provides a cooling sensation upon application and an extra boost of moisturizing hyaluronic acid to help support post-laser treatment recovery.

Apply as directed, or up to 2-3 times per day. Allow the product to dry thoroughly before applying other products. Avoid direct contact with the eyes. If contact occurs rinse thoroughly with water.

Revitalizing Essence( plated )™ SkinScience Revitalizing Essence
A daily infusion of Renewosomes™ provides a barrier to maintain luminosity and overall skin glow. It provides a calming and radiance-boosting effect against the signs of aging.

Transition to the essence once severe symptoms have been managed by the higher concentration serum.

Apply two pumps as part of your evening regimen.

Intensive Repair Serum( plated )™ SkinScience Intensive Repair Serum
A powerful, concentrated blend of Renewosomes™, designed to correct damaged skin. Enriched with growth factors and antioxidants that help your skin rejuvenate the appearance of wrinkles, brown spots, redness, and dullness.

Apply two pumps as part of your evening regimen.



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Kirsten S.
Linda and staff are amazing. I am always very happy with my treatment results. It is apparent that she researches various technologies and techniques. The applications are always evolving with new and improved products. Highly recommended.
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Suzanne P.
Excellent service and an overall pleasant experience. Victoria was professional and knowledgeable. She proposed treatments addressing both my anesthetic and medical concerns.. I could not be happier with the results. Also, the Receptionist, Mattie, was pleasant and efficient. I look forward to future treatments.
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Lisa M.
Hayes Valley is the best! Kate did an incredible job with Dysport removing the wrinkles from my forehead, Sandra gave me great abs and glutes with Emsculpt, and Linda gave me my youthful facial structure back with Sculptra. These women are truly amazing. So glad that I found them!
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Gene V.
I love Hayes Valley Medical and Esthetics! I've been coming for a while now for Botox and filler treatments. Linda is AMAZING! She knows just the right amount of product needed in all the right places to bring out my best facial features. I feel more handsome every time!!

The front desk staff are super sweet and helpful. They always ask exactly what I want and I never feel like I'm being 'upsold' or encouraged to do anything other than what I came in for. I would highly recommend HVME to anybody that is on the unsure about trying some of the services they offer. You won't be disappointed. Thank you!!
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Julie S.
This was my first experience with any filler/injection treatment and it was very pleasant, professional and everyone there made me feel safe, welcome and I felt very knowledgeable coming out of my treatment about what to expect. I will absolutely be back!
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Tina B.
Diana at the front desk is so sweet, the medical assistant was amazing & personable and Kate who did my procedure is my favorite! As I walked out and met my husband, I told him how much I enjoy being there & what a good vibe Hayes has.
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Cher B.
Sheila and Linda took great care of me and I look younger and vibrant.  I do not trust anyone else for injectables.  Linda is careful, thoughtful, and respectful of one’s budget. I have followed her from Marin into SF and I will continue to follow her where ever she practices.
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Emily N.
I highly recommend Hayes Valley Medical & Esthetics!! All the front desk staff are warm, friendly and professional and Denise is the best for laser, she goes above to make you feel comfortable and at ease. Andrea is exceptional at explaining the services they offer. They are the best in SF in my opinion and I do my research!
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Kathleen F.
Excellent customer service, advice, and care. Botox and Microneedling. Melonie is a gem. She is extremely knowledgable, sincere and honest. Everyone here is helpful, They carry a fabulous array of skin products too. I am so pleased with my results!
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Receive 10% off your first treatment at either location!