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Make Your Skin Young Again

Rewind Time. Reveal younger skin with the Clinical Power Trio+ – DefenAge’s core three-piece regimen: 2-Minute Reveal Masque, 24/7 Barrier Balance Cream, and 8-in-1 BioSerum.

We are proud to be one of the first in the SF/Marin Area to offer this paradigm-shifting, anti-aging marvel from DefenAge. We believe in the skin care science behind this proven line of products. Clean skincare is DefenAge’s philosophy and one of their key core values so they are committed to the highest clean beauty standards.

defenage awards

Visible correction of up to 15 signs of aging in just six weeks!*
• Revives youthful firmness
• Brightens age spots
• Defines contours
• Smooths lines
• Diminishes wrinkles
• Unclogs & minimizes pores
• Evens skin tone
• Corrects surface imperfections
• Revives clarity
• Replenishes moisture
• Repairs dryness
• Refines texture
• Renews softness
• Revitalizes dullness
• Calms redness

DefenAge Skincare offers fragrance-free options and, as part of their commitment to clean beauty, all of their products do not contain:
Human- or animal- derived ingredients, parabens or formaldehyde-releasing preservatives, sulfates, irritating acids or abrasives, strong emulsifiers, chemical sunscreens, mineral oil, petrolatum or paraffin, colorants, phthalates, BPA, BHT/BHA, propylene glycol, triethanolamine, or gluten ingredients (no wheat, oats, barley).

Inspired by the recent discovery of the skin’s regeneration process, the scientists at DefenAge have identified how to unlock the key to youth with powerful peptides called Age-Repair Defensins™.


Scientific research shows that defensins can reprogram skin to become younger every day, reversing aging.

defenage-mag-primeRead “Stem Cells In Dermatology And Skin Anti-aging: A Defensins Study”.
“Since aging is so intimately tied to stem cell integrity, one of the major goals of stem cell biology and regenerative medicine is how one can use these cells to reverse aging and the associated dysfunctions that comes with it…

Also review “Clinical trial results of Defensins-containing anti-aging skin care products” from the Journal of Drugs in Dermatology.
“…defensin containing skin care regimen of three products significantly improves the visual appearance, coarse and fine wrinkles, appearance of pores, uneven texture, and thickness of the epidermis of aging skin… Collectively, these findings may represent a paradigm shift in cosmeceutical skin care.”
Before and After Photos

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“I’ve been using for 3 months now & LOVE the results!! Have been reading up on “age-repair Defensins” – love how it uses the action of your own body’s natural repair mechanism. My result has been a return to more youthful looking skin texture & tone. I am a pilates instructor & hear about all the latest rejuvenation techniques – alot of my students have become converts!”
Ricky G.

newbeauty magazine 2018 award winnerDefenAge was a winner of the coveted NEWBEAUTY Best-of Awards for two years in a row:
2020 – “Best Eye Cream For Dark Circles”
2019 – “Best Brightening Mask” – 2-Minute Reveal Masque



The Clinical Power Trio+ products may be purchased separately (details below), but you save by purchasing them combined. Each formula in the Clinical Power Trio is infused with a collection of high-functioning, eco-friendly ingredients and multi-action age-correcting technologies to reverse visible and textural aging on a global scale, regardless of age, ethnicity or skin condition. Results begin within minutes.

The Clinical Power Trio includes:
• 2-Minute Reveal Masque | 2.5 oz.
• 24/7 Barrier Balance Cream | 1.5 fl. oz.
• 8-in-1 BioSerum | 1.5 fl. oz.


defenage hand and body lotion10 Luxe Hand & Body Cream
The first-ever defensin-containing cream for the hands and body! Infused with DefenAge’s famed and exclusive defensin-molecules, this product bathes skin in the most powerful age-reversal skincare technology on the market.

• Visibly enhances firmness and elasticity.
• Improves the appearance of crepey skin.
• Provides both instant and long-lasting hydration, including in dry climates. Skin feels firmer and plumper immediately.
• Promotes the skin’s natural laminin, hyaluronic acid, and elastin.
• Improves visible skin thickness.
• Effective on elbows and knees; visibly revives and revitalizes texture.
• Smooths and softens the skin on the hands.
• Beneficial in combination with body contouring procedures to improve skin firmness and overall skin quality.
• Recommended for use with skin rejuvenation treatments such as peels, IPL, microneedling, and laser treatments to amplify results and reduce the look of pigmentation, sun damage, crepeness, and skin laxity.

“I am thrilled to introduce the 10 Luxe Hand & Body Cream to my patients,” says dermatologist Melda Isaac, MD, Washington, DC. “The feeling is elegant. The smell is pleasant and clean. It absorbs quickly and is not at all sticky or tacky. Immediately, the skin feels firmer and plumper.”

How To Use
Apply once or twice daily after bathing or showering. Smooth and lightly massage the cream from ankles to waist, then hands, arms, shoulders and hands, followed by rest of the body. Apply 8-in-1 BioSerum on elbows, knees, and other challenging areas to maximize results.

2-Minute Reveal Masque defenage two minute Masque mask
This resurfacing masque will reveal the healthy skin beneath surface debris in a matter of minutes. A blend of enzymes and exfoliating crystals break down dead skin and soften surface layers. When used once or twice a week, it helps the products that follow work on skin layers more effectively. Adding water then melts the crystals for an instantly refreshed, younger-looking complexion. Free from microbeads and fragrance.

How To Use
Start with clean dry skin. Apply a quarter’s worth of the cream. The mask is thick and at first use feels like it won’t spread but the warmth of your fingers is all it needs. Gently massage for about twenty seconds. The cream softens and you can gently feel the sugar crystals on your face. Wait two minutes. Then with wet finger tips, massage until crystals are completely dissolved and rinse clean.

24/7 Barrier Balance Cream24/7 Barrier Balance Cream
This deeply moisturizing lightweight cream combines multiple anti-aging technologies to promote youthful skin. It works with a proprietary peptide blend, along with soothing niacinamide and hyaluronic acid, to help you achieve a smooth and even complexion. Botanical antioxidants from cranberry and rosemary protect skin from environmental free radical damage, while essential amino acids boost collagen and elastin production for a firm facial contour. The dermatologist-tested formula is effective for all skin types, ages and ethnicities.

How To Use
Twice daily after cleansing, place three to four pumps of cream onto fingertips. While skin is still moist, lightly massage over entire face, neck and décolletage. Avoid eye area.

8-in-1 BioSerum24/7 Barrier Balance Cream
This nourishing anti-aging serum works in numerous ways to promote a youthful, healthy complexion by smoothing fine wrinkles, calming inflammation and boosting collagen production. It combines ingredient technologies equal to eight separate serums to rejuvenate and restore vitality to skin. Niacinamide soothes and promotes microcirculation, while a select blend of peptides and proprietary Age-Repair Defensins™ smooth fine lines, brighten hyperpigmentation and firms the skin.

How To Use
Apply twice a day right after applying 24/7 Barrier Balance Cream. Place two pumps of serum onto fingertip. Lightly massage first around eyes, then over entire face, neck and décolletage. Follow with sunscreen.

3D Eye Radiance CreamDefenage-3D-Eye-Radiance-Cream
This potent nourishing cream contains Age-Repair Defensins™ to target fine lines, dark circles, crepiness and regenerate delicate eyelid skin.

• Technology-loaded treatment with extended performance.
• Visibly lifts, firms and smooths upper eyelids, fades dark circles and puffiness.
• Smooths the appearance of crow’s feet and fine lines.
• A patent-protected metal applicator with Cooling Tip Technology fosters gentle “finger-free” application to help preserve the delicate skin around the eyes, providing a soothing and cooling sensation upon contact.

The Fly Kit includes the following and is TSA-friendly:
• 2-Minute Reveal Masque | 0.75 oz.
• 24/7 Barrier Repair Cream | 0.5 fl. oz.
• 8-in-1 BioSerum | 0.33 fl. oz.

1-Step Multi-Cleanse with Natural Prebioticsdefenage-multi-cleanser
This innovative cleanser effortlessly melts away makeup, oil, dirt, surface debris and air pollution in seconds. The soap-free formula gently liquefies water-resistant eye makeup (even water-proof eyeliner and mascara) with ease while hydrating the skin and maintaining the integrity of the sensitive skin around the eye area.

Quick and Gentle Cleansing:
• Natural prebiotics balance the skin’s delicate ecology.
• Helps body’s natural defensins.
• Effective for all ages, skin types, and ethnicities.
• Free from parabens, dehydrating surfactants (soaps), fragrance, animal and human-derived ingredients.
Peer-reviewed study highlights the use of defensins as a new therapy for skin rejuvenation.

6-Week Perfection Neck Cream6-Week Perfection Neck Cream
Designed to correct the challenging deep lines, folds, and impacts of gravity on the fragile skin of the neck where aging is often more noticeable.

• Reverses a wide range of neck-specific signs of skin aging.
• Reduces fine lines, soothes deep lines and folds. Gives the neck a smooth appearance.
• Lifts, firms, and tightens sagging neck skin.
• Visibly improves skin thickness.
• Leaves the neck looking and feeling youthful.
• Designed to produce treatment-like results.

How To Use
Twice daily after cleansing, place one pump of the neck tightening cream onto fingertips. While skin is still moist, lightly massage cream onto the skin with short lifting motions using fingers of right hand to apply to left side of neck and décolletage, and vice versa. Start above breast line and work up to jawline and back of neck. Wait 30 seconds, then apply 8-in-1 BioSerum.

See our blog article DefenAge Skincare 6-Week Perfection Neck Cream

DefenAge Skincare FAQ

See our blog article DefenAge Skincare – Making Waves!

What’s The Science?

Two articles that feature DefenAge’s proprietary technology were each named “Top Aesthetic Publication”. The first winning article, which was published by the Journal of Drugs in Dermatology, describes a multi-center clinical trial of DefenAge’s signature regimen. The data from the article validates DefenAge as a best-in-class anti-aging solution.

The second winning article is entitled, “Stem Cells in Dermatology and Anti-aging Care of the Skin“. It highlights the advantages of defensin-based technology over older generations of skin care products and describes defensins as a new way to target skin aging. The article is co-authored by renowned dermatologist Amy Forman Taub, MD, FAAD, and a stem cell researcher from Wisconsin University, Kim Pham.

* A six-week clinical study of participants ages 48 to 68 using this regimen: 2-Minute Reveal Masque one-to-two times a week plus 24/7 Barrier Repair Cream and 8-in-1 BioSerum twice daily. Participants realized an overall improvement in skin evenness (a global measurement of the skin surface roughness including pore and wrinkle size and the even or coarse texture of the skin) as measured using QuantifiCare™ Clinical Imaging System as compared to QuantifiCare’s Reference Population Database of normal aging skin for that age group. DefenAge “youthened” skin appearance up to 18 years (+ or – 4, average per group). Individual results may vary.

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