DefenAge Pro Skincare

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Make Your Skin Young Again

Rewind Time. Reveal younger skin with the Clinical Power Trio+ – DefenAge’s core three-piece regimen: 2-Minute Reveal Masque, 24/7 Barrier Balance Cream, and 8-in-1 BioSerum.

We are proud to be one of the first in the SF/Marin Area to offer this paradigm-shifting, anti-aging marvel from DefenAge. We believe in the skin care science behind this proven line of products. Clean skincare is DefenAge’s philosophy and one of their key core values so they are committed to the highest clean beauty standards.

DefenAge PRO Exclusive daily regimen directions

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Visible correction of up to 15 signs of aging in just six weeks!*
• Revives youthful firmness
• Brightens age spots
• Defines contours
• Smooths lines
• Diminishes wrinkles
• Unclogs & minimizes pores
• Evens skin tone
• Corrects surface imperfections
• Revives clarity
• Replenishes moisture
• Repairs dryness
• Refines texture
• Renews softness
• Revitalizes dullness
• Calms redness

DefenAge Skincare offers fragrance-free options and, as part of their commitment to clean beauty, all of their products do not contain:
Human- or animal- derived ingredients, parabens or formaldehyde-releasing preservatives, sulfates, irritating acids or abrasives, strong emulsifiers, chemical sunscreens, mineral oil, petrolatum or paraffin, colorants, phthalates, BPA, BHT/BHA, propylene glycol, triethanolamine, or gluten ingredients (no wheat, oats, barley).

Inspired by the recent discovery of the skin’s regeneration process, the scientists at DefenAge have identified how to unlock the key to youth with powerful peptides called Age-Repair Defensins.


Scientific research shows that defensins can reprogram skin to become younger every day, reversing aging.

defenage-mag-primeRead “Stem Cells In Dermatology And Skin Anti-aging: A Defensins Study”.
“Since aging is so intimately tied to stem cell integrity, one of the major goals of stem cell biology and regenerative medicine is how one can use these cells to reverse aging and the associated dysfunctions that comes with it…

Also review “Clinical trial results of Defensins-containing anti-aging skin care products” from the Journal of Drugs in Dermatology.
“…defensin containing skin care regimen of three products significantly improves the visual appearance, coarse and fine wrinkles, appearance of pores, uneven texture, and thickness of the epidermis of aging skin… Collectively, these findings may represent a paradigm shift in cosmeceutical skin care.”

Before and After Photos

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“I’ve been using for 3 months now & LOVE the results!! Have been reading up on “age-repair Defensins” – love how it uses the action of your own body’s natural repair mechanism. My result has been a return to more youthful looking skin texture & tone. I am a pilates instructor & hear about all the latest rejuvenation techniques – alot of my students have become converts!”
Ricky G.

newbeauty magazine 2018 award winnerDefenAge was a winner of the coveted NEWBEAUTY Best-of Awards for two years in a row:
2020 – “Best Eye Cream For Dark Circles”
2019 – “Best Brightening Mask” – 2-Minute Reveal Masque


Clinical Power Trio PRO EXCLUSIVEThe Clinical Power Trio PRO EXCLUSIVE products may be purchased separately (details below), but you save by purchasing them combined. Each formula in the Clinical Power Trio is infused with a collection of high-functioning, eco-friendly ingredients and multi-action age-correcting technologies to reverse visible and textural aging on a global scale, regardless of age, ethnicity or skin condition. Results begin within minutes.

The Clinical Power Trio PRO EXCLUSIVE includes:
• 2-Minute Reveal Masque | 3.5 oz.
• 24/7 Barrier Balance Cream | 1.5 fl. oz.
• 8-in-1 BioSerum | 1.5 fl. oz.


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8-in-1 BioSerum PRO EXCLUSIVE 8-in-1 BioSerum PRO EXCLUSIVE
This nourishing anti-aging serum works in numerous ways to promote a youthful, healthy complexion by smoothing fine wrinkles, calming inflammation and boosting collagen production. It combines ingredient technologies equal to eight separate serums to rejuvenate and restore vitality to skin. Niacinamide soothes and promotes microcirculation, while a select blend of peptides and proprietary Age-Repair Defensins™ smooth fine lines, brighten hyperpigmentation and firms the skin.

How To Use
Apply twice a day right after applying 24/7 Barrier Balance Cream. Place two pumps of serum onto fingertip. Lightly massage first around eyes, then over entire face, neck and décolletage. Follow with sunscreen.

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24/7 Barrier Balance Cream PRO EXCLUSIVE 24/7 Barrier Balance Cream PRO EXCLUSIVE
This deeply moisturizing lightweight cream combines multiple anti-aging technologies to promote youthful skin. It works with a proprietary peptide blend, along with soothing niacinamide and hyaluronic acid, to help you achieve a smooth and even complexion. Botanical antioxidants from cranberry and rosemary protect skin from environmental free radical damage, while essential amino acids boost collagen and elastin production for a firm facial contour. The dermatologist-tested formula is effective for all skin types, ages and ethnicities.

How To Use
Twice daily after cleansing, place three to four pumps of cream onto fingertips. While skin is still moist, lightly massage over entire face, neck and décolletage. Avoid eye area.

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2-Minute Reveal Masque PRO EXCLUSIVE2-Minute Reveal Masque PRO EXCLUSIVE
This resurfacing masque will reveal the healthy skin beneath surface debris in a matter of minutes. A blend of enzymes and exfoliating crystals break down dead skin and soften surface layers. When used once or twice a week, it helps the products that follow work on skin layers more effectively. Adding water then melts the crystals for an instantly refreshed, younger-looking complexion. Free from microbeads and fragrance.

How To Use
Start with clean dry skin. Apply a quarter’s worth of the cream. The mask is thick and at first use feels like it won’t spread but the warmth of your fingers is all it needs. Gently massage for about twenty seconds. The cream softens and you can gently feel the sugar crystals on your face. Wait two minutes. Then with wet finger tips, massage until crystals are completely dissolved and rinse clean.

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1-Step Multi-Cleanse with Natural Prebiotics PRO EXCLUSIVE1-Step Multi-Cleanse with Natural Prebiotics PRO EXCLUSIVE
This innovative cleanser effortlessly melts away makeup, oil, dirt, surface debris and air pollution in seconds. The soap-free formula gently liquefies water-resistant eye makeup (even water-proof eyeliner and mascara) with ease while hydrating the skin and maintaining the integrity of the sensitive skin around the eye area.

Quick and Gentle Cleansing:
• Natural prebiotics balance the skin’s delicate ecology.
• Helps body’s natural defensins.
• Effective for all ages, skin types, and ethnicities.
• Free from parabens, dehydrating surfactants (soaps), fragrance, animal and human-derived ingredients.

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The Fly Kit PRO EXCLUSIVE includes the following and is TSA-friendly:Fly Kit PRO EXCLUSIVE
• 2-Minute Reveal Masque | 0.75 oz.
• 24/7 Barrier Repair Cream | 0.5 fl. oz.
• 8-in-1 BioSerum | 0.33 fl. oz.

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3D Eye Radiance Cream PRO EXCLUSIVEDefenage-3D-Eye-Radiance-Cream
This potent nourishing cream contains Age-Repair Defensins™ to target fine lines, dark circles, crepiness and regenerate delicate eyelid skin.

• Technology-loaded treatment with extended performance.
• Visibly lifts, firms and smooths upper eyelids, fades dark circles and puffiness.
• Smooths the appearance of crow’s feet and fine lines.
• A patent-protected metal applicator with Cooling Tip Technology fosters gentle “finger-free” application to help preserve the delicate skin around the eyes, providing a soothing and cooling sensation upon contact.

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6-Week Perfection Neck Cream PRO EXCLUSIVE6-Week Perfection Neck Cream
Designed to correct the challenging deep lines, folds, and impacts of gravity on the fragile skin of the neck where aging is often more noticeable.

• Reverses a wide range of neck-specific signs of skin aging.
• Reduces fine lines, soothes deep lines and folds. Gives the neck a smooth appearance.
• Lifts, firms, and tightens sagging neck skin.
• Visibly improves skin thickness.
• Leaves the neck looking and feeling youthful.
• Designed to produce treatment-like results.

How To Use
Twice daily after cleansing, place one pump of the neck tightening cream onto fingertips. While skin is still moist, lightly massage cream onto the skin with short lifting motions using fingers of right hand to apply to left side of neck and décolletage, and vice versa. Start above breast line and work up to jawline and back of neck. Wait 30 seconds, then apply 8-in-1 BioSerum.

See our blog article DefenAge Skincare 6-Week Perfection Neck Cream

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DefenAge Skincare FAQ

See our blog article DefenAge Skincare – Making Waves!

What’s The Science?

Two articles that feature DefenAge’s proprietary technology were each named “Top Aesthetic Publication”. The first winning article, which was published by the Journal of Drugs in Dermatology, describes a multi-center clinical trial of DefenAge’s signature regimen. The data from the article validates DefenAge as a best-in-class anti-aging solution.

The second winning article is entitled, “Stem Cells in Dermatology and Anti-aging Care of the Skin“. It highlights the advantages of defensin-based technology over older generations of skin care products and describes defensins as a new way to target skin aging. The article is co-authored by renowned dermatologist Amy Forman Taub, MD, FAAD, and a stem cell researcher from Wisconsin University, Kim Pham.

* A six-week clinical study of participants ages 48 to 68 using this regimen: 2-Minute Reveal Masque one-to-two times a week plus 24/7 Barrier Repair Cream and 8-in-1 BioSerum twice daily. Participants realized an overall improvement in skin evenness (a global measurement of the skin surface roughness including pore and wrinkle size and the even or coarse texture of the skin) as measured using QuantifiCare™ Clinical Imaging System as compared to QuantifiCare’s Reference Population Database of normal aging skin for that age group. DefenAge “youthened” skin appearance up to 18 years (+ or – 4, average per group). Individual results may vary.

Peer-reviewed study highlights the use of defensins as a new therapy for skin rejuvenation.



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Kirsten S.
Linda and staff are amazing. I am always very happy with my treatment results. It is apparent that she researches various technologies and techniques. The applications are always evolving with new and improved products. Highly recommended.
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Suzanne P.
Excellent service and an overall pleasant experience. Victoria was professional and knowledgeable. She proposed treatments addressing both my anesthetic and medical concerns.. I could not be happier with the results. Also, the Receptionist, Mattie, was pleasant and efficient. I look forward to future treatments.
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Lisa M.
Hayes Valley is the best! Kate did an incredible job with Dysport removing the wrinkles from my forehead, Sandra gave me great abs and glutes with Emsculpt, and Linda gave me my youthful facial structure back with Sculptra. These women are truly amazing. So glad that I found them!
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Gene V.
I love Hayes Valley Medical and Esthetics! I've been coming for a while now for Botox and filler treatments. Linda is AMAZING! She knows just the right amount of product needed in all the right places to bring out my best facial features. I feel more handsome every time!!

The front desk staff are super sweet and helpful. They always ask exactly what I want and I never feel like I'm being 'upsold' or encouraged to do anything other than what I came in for. I would highly recommend HVME to anybody that is on the unsure about trying some of the services they offer. You won't be disappointed. Thank you!!
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Julie S.
This was my first experience with any filler/injection treatment and it was very pleasant, professional and everyone there made me feel safe, welcome and I felt very knowledgeable coming out of my treatment about what to expect. I will absolutely be back!
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Tina B.
Diana at the front desk is so sweet, the medical assistant was amazing & personable and Kate who did my procedure is my favorite! As I walked out and met my husband, I told him how much I enjoy being there & what a good vibe Hayes has.
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Cher B.
Sheila and Linda took great care of me and I look younger and vibrant.  I do not trust anyone else for injectables.  Linda is careful, thoughtful, and respectful of one’s budget. I have followed her from Marin into SF and I will continue to follow her where ever she practices.
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Emily N.
I highly recommend Hayes Valley Medical & Esthetics!! All the front desk staff are warm, friendly and professional and Denise is the best for laser, she goes above to make you feel comfortable and at ease. Andrea is exceptional at explaining the services they offer. They are the best in SF in my opinion and I do my research!
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Kathleen F.
Excellent customer service, advice, and care. Botox and Microneedling. Melonie is a gem. She is extremely knowledgable, sincere and honest. Everyone here is helpful, They carry a fabulous array of skin products too. I am so pleased with my results!
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